General description
A cell-permeable pyrazone compound that irreversibly (presumably via covalent modification) inhibits ubiquitin-activating enzyme E1 activity (IC50﹤10 µM in cell-free E1 ubiquitination reactions), while exhibiting little or no activity against E3, E2, or caspase enzymatic activity. Blocks ubiquitination-dependent protein degradation and other ubiquitination-mediated cellular activities. E1 inactivation by PYR-41 or other means has been shown to result in an overall elevation of sumoylation.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Other Notes
Yang, Y., et al. 2007. Cancer Res.67, 9472.
Packaging
Packaged under inert gas
25 mg in Plastic ampoule
Reconstitution
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. At room temperature, compound will undergo ~1% decomposition per day.
Warning
Toxicity: Irritant (B)
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